Tottenham s clash with Manchester City is the pick of the bunch from the EFL Cup fourth-round draw.
City sealed their progress from round three by beating Watford 2-1 at home on Tuesday, while Spurs overcame Coventry City last week.
The Premier League heavyweights will go head-to-head for a place in the quarter-finals, while holders Liverpool face a tough trip to in-form Brighton.
Manchester United, who were in Europa League action on Wednesday, were drawn against Leicester City. Chelsea will face the winner of AFC Wimbledon s postponed match with Newcastle United, which will take place at St James Park next week.
Aston Villa and Crystal Palace will face off in another all-Premier League encounter, while Southampton and Brentford were drawn at home against Championship opposition in Sheffield Wednesday and Stoke City respectively.
Arsenal, 5-1 victors over Bolton Wanderers, will visit Preston North End.
The Carabao Cup fourth round draw is complete
— Sky Sports Football (@SkyFootball)
Fourth-round draw in full:
Brentford v Sheffield Wednesday
Southampton v Stoke City
Tottenham v Man City
AFC Wimbledon / Newcastle United v Chelsea
Man Utd v Leicester City
Brighton v Liverpool
Preston North End v Arsenal
Aston Villa v Crystal Palace